Sandro began playing guitar as a self-taught musician and then studied at the Nino Donzelli Centre for Musical Studies in Cremona. Since 1979 he has devoted himself mainly to jazz, meeting other young musicians from northern Italy, and becoming part of the Gianni Cazzola Quintet. In the eighties he had a chance to play with many Italian musicians (Enrico Rava, Gianni Basso, Massimo Urbani, Luigi Bonafede, Larry Nocella) and American artists such as Lee Konitz, Mel Lewis, Al Grey, Jimmy Woodie, Sal Nistico, Dave Schnitter, Gerry Mulligan, Lew Tabackin and Jimmy Owens.
Between 1988 and 1999 he played in the "Reunion" quintet with Danilo Rea and Roberto Gatto and recorded with Larry Schneider. In 1990 he became a member of "Keptorchestra" and in 1993 he released the CD "Felix" with his own band and "Funny Men" with Mauro Negri and Paolo Birro. Sandro Gibellini has also played on many records of the pop artist Mina.
In March 2000 he performed as a member of Italian All-Stars in New York and at the North Carolina International Jazz Festival and in December 2000 in Cuba at the Havana International Jazz Festival.